Discontinue use if photosensitivity, peripheral neuropathy, 1st sign of tendinitis or hypoglycemia occur; at 1st appearance of skin rash, jaundice or any other sign of hypersensitivity;
Clostridium difficile-associated diarrhea is suspected or confirmed. Not to be used if signs of tendinopathy occurs. Avoid use in patients w/ known history of myasthenia gravis; prolonged QTc interval, uncorrected electrolyte disorders eg, hypokalemia or hypomagnesemia. Increased risk of retinal detachment. History of aneursym disease, preexisting aortic aneursym &/or aortic dissection, risk factors or conditions predisposing for aortic aneurysm & dissection eg, Marfan syndrome, vascular Ehlers-Danlos syndrome, Takayasu arteritis, giant cell arteritis, Behcet's disease, HTN, known atherosclerosis. Previous tendon disorder eg, RA; CNS diseases eg, epilepsy or predisposed to convulsions; ongoing proarrhythmic conditions eg, acute myocardial ischaemia; G6PD deficiency; risk factors or conditions predisposing for heart valve regurgitation/incompetence eg, congenital or preexisting heart valve disease, connective tissue disorders, Turner syndrome, RA, infective endocarditis; kidney, heart or lung transplants. Monitor blood glucose in diabetic patients. Ensure adequate hydration during treatment. Avoid excessive sun or UV light exposure. Avoid use of corticosteroids; class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmics. Concurrent use w/ erythromycin, antipsychotics & TCAs. May affect ability to drive & use machines. Renal & hepatic impairment. Not to be used during pregnancy & lactation. Childn & adolescents <18 yr. Elderly >60 yr.
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