Sign Out
Pharmacology: The drug acts by binding with phospholipids in cell membrane of susceptible fungi with a resultant change in membrane permeability.
Pharmacokinetics: Small amounts of clotrimazole are absorbed systemically when the drug is administered intravaginally. About 3 - 10% of an intravaginal dose of the drug reaches systemic circulation, principally as metabolites. The finding of low clotrimazole concentrations in serum and high concentration in vaginal secretions suggest that it remains in the vagina for 48 hours, and in some cases 72 hours, in fungicidal concentration.
Microbiology: Cotren inhibits or kills many fungi, including yeasts and dermatophytes; it is also effective against trichomonas vaginalis.
