Each 100 gm contains Clobetasol Propionate 0.05 gm in a white base cream, Methyl paraben 0.21 gm (as preservative), Propyl paraben 0.21 gm (as preservative).
Clobetasol propionate is a very active topical corticosteroid which is of particular value when used in short courses for the treatment of the more resistant dermatoses eg psoriasis (excluding wide spread plaque psoriasis), recalcitrant eczemas, lichen planus, discoid lupus erythematosus and other conditions which do not respond satisfactorily to less active steroids.
ADMINISTRATION: Apply CLOBET CREAM to the affected area, once or twice daily until improvement occurs or as directed.
Because of topical application, the overdosage would not occurred.
Rosacea, acne and perioral dermatitis. Primary cutaneous viral infections (eg. herpes simplex, chickenpox) and hypersensitivity to the preparation.
Long term continuous therapy with CLOBET CREAM in infants and children should be avoided since it may induce adrenal suppression.
It should not be used extensively in pregnancy, either in large amounts or for prolonged periods.
Appropriate chemotherapy should be used whenever secondary infections occured.
If used in childhood or on the face, courses should be limited if possible to 5 days and occlusion should not be used.
The face, more than other areas of the body, may exhibit atrophic changes after prolonged treatment with potent topical corticosteroids. This must be borne in mind when treating such conditions as psoriasis, discoid lupus erythematosus and severe eczema.
If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye, as glaucoma might result.
Topical corticosteroids may be hazardous in psoriasis for a number of reasons including rebound relapses, development of tolerance, risk of generalised pascular psoriasis and development of local or systemic toxicity due to impaired barrier function of the skin.
If used in psoriasis, careful patient supervision is important.
It should not be used extensively in pregnancy, either in large amounts or for prolonged periods.
Provided the weekly dosage is <50 g in adults, any pituitary-adrenal suppression is likely to be transient with a rapid return to normal values once the short course of steroid therapy has ceased. The same applies to children given proportionate dosage. Use of occlusive dressings increases the absorption of topical corticosteroids.
Prolonged and intensive treatment with highly-active corticosteroid preparations may cause atrophic changes, eg striae, thinning of the skin, and dilation of the superficial blood vessels, and particularly when occlusive dressings are used, or where skin folds are involved.
In some instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the disease. If signs of hypersensitivity appear, applications should be stopped immediately. As with other steroids, prolonged use of large amounts, or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism.
Store at temperature not exceeding 30°C.
D07AD01 - clobetasol ; Belongs to the class of very potent (group IV) corticosteroids. Used in the treatment of dermatological diseases.
Clobet cream 0.05 %
10 g x 1's
Sign Out
