Clobet Adverse Reactions

Provided the weekly dosage is <50 g in adults, any pituitary-adrenal suppression is likely to be transient with a rapid return to normal values once the short course of steroid therapy has ceased. The same applies to children given proportionate dosage. Use of occlusive dressings increases the absorption of topical corticosteroids.
Prolonged and intensive treatment with highly-active corticosteroid preparations may cause atrophic changes, eg striae, thinning of the skin, and dilation of the superficial blood vessels, and particularly when occlusive dressings are used, or where skin folds are involved.
In some instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the disease. If signs of hypersensitivity appear, applications should be stopped immediately. As with other steroids, prolonged use of large amounts, or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism.