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BLES (bovine lipid extract surfactant) is indicated for rescue treatment of Neonatal Respiratory Distress Syndrome (NRDS/Hyaline Membrane Disease).
For infants with NRDS confirmed by X-ray and who require mechanical ventilation, with arterial to alveolar oxygen ratio (PaO2/PAO2) <0.22, BLES is to be given as soon as possible after the oxygenation criteria are met.
The use of BLES in infants less than 380g or greater than 4460g birth weight has not been evaluated in controlled trials.
