Each ml of suspension contains 27mg of phospholipid and 176-500μg of surfactant associated protein's SP-B and SP-C. Contains no preservatives.
BLES (bovine lipid extract surfactant) is extracted from bovine lung surfactant. The manufacturing process removes hydrophilic proteins, the majority of which would be surfactant-associated protein SP-A, and selects for hydrophobic phospholipids and surfactant-associated proteins SP-B and SP-C.
Drug Substance: Bovine lipid extract surfactant is an extract of bovine pulmonary surfactant that contains numerous phospholipids and hydrophobic surfactant associated proteins SP-B and SP-C.
The phospholipids are present in the following ratio, expressed as a percent of the total phospholipid concentration. (See Table 1.)
Click on icon to see table/diagram/image
The hydrophobic proteins are surfactant-associated proteins SP-B and SP-C present at 6.5 - 18.5 μg/mg phospholipid.
Product Characteristics: Phospholipids and hydrophobic proteins SP-B and SP-C are isolated from bovine lung surfactant, then suspended in a sodium chloride and calcium chloride solution, which is heat sterilized in single-use vials.
Excipients/Inactive Ingredients: 0.1M Sodium chloride, 0.0015M Calcium chloride, Sterile water for Irrigation and Nitrogen.