BeneFIX Caution For Usage

Special precautions for disposal and other handling: Reconstitute lyophilized BeneFIX powder for injection with the supplied diluent (0.234% sodium chloride solution) from the pre-filled syringe provided. Once the diluent has been injected into the vial, gently rotate the vial until all powder is dissolved. After reconstitution, the solution is drawn back into the syringe and infused.
The solution should be clear and colorless. The solution should be discarded if visible particulate matter or discoloration is observed. The product does not contain a preservative, and the reconstituted solution should be used within 3 hours after reconstitution.
All unused solution, empty vials and used needles and syringes must be discarded in accordance with local requirements.
Incompatibilities: In the absence of incompatibility studies, reconstituted BeneFIX must not be administered in the same tubing or container with other medicinal products. Only the provided infusion set should be used. Treatment failure can occur as a consequence of human coagulation factor IX adsorption to the internal surfaces of some infusion equipment.