Individualized dosage. Early haemarthrosis, muscle/oral bleeding
20-40 IU/dL every 24 hr for at least 1 day. More extensive haemarthrosis, muscle bleeding or haematoma
30-60 IU/dL infusion every 24 hr for 3-4 days. Life-threatening haemorrhage
60-100 IU/dL infusion every 8-24 hr until threat resolved. Minor surgery including tooth extraction
30-60 IU/dL every 24 hr for at least 1 day. Major surgery (pre- & post-op)
80-100 IU/dL infusion every 8-24 hr until adequate wound healing, followed by therapy for at least another 7 days to maintain factor IX activity of 30-60 IU/dL. Long-term prophylaxis for patient w/ severe haemophilia B
100 IU/kg once wkly. Routine secondary prophylaxis for previously treated patient
40 IU/kg at 3- to 4-day intervals.