Individualized dosage.
Early haemarthrosis, muscle/oral bleeding 20-40 IU/dL every 24 hr for at least 1 day.
More extensive haemarthrosis, muscle bleeding or haematoma 30-60 IU/dL infusion every 24 hr for 3-4 days.
Life-threatening haemorrhage 60-100 IU/dL infusion every 8-24 hr until threat resolved.
Minor surgery including tooth extraction 30-60 IU/dL every 24 hr for at least 1 day.
Major surgery (pre- & post-op) 80-100 IU/dL infusion every 8-24 hr until adequate wound healing, followed by therapy for at least another 7 days to maintain factor IX activity of 30-60 IU/dL.
Long-term prophylaxis for patient w/ severe haemophilia B 100 IU/kg once wkly.
Routine secondary prophylaxis for previously treated patient 40 IU/kg at 3- to 4-day intervals.
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