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Tablet: Symptoms: Acyclovir is only partly absorbed in the gastrointestinal tract. It is unlikely that serious toxic effects would occur if a dose of up to 5 g were taken on a single occasion. No data are available on the consequences of the ingestion of higher doses.
Single intravenous doses of up to 80 mg/kg have been inadvertently administered without adverse effects.
Treatment: Ingestion of doses of acyclovir in excess of 5 g warrants close observation of the patient.
Acyclovir is dialysable.
Cream: Overdosage by topical application of Acylete cream is unlikely because of limited transcutaneous absorption.
