Acylete Dosage/Direction for Use

Tablet: Adults, children and geriatric: Acylete Tablets should be applied to the lesions or impending lesions as early as possible after the start of an infection.
Dosage for treatment of herpes simplex in adults: For treatment of herpes simplex infections, 200 mg Acyclovir should be taken 5 times daily at approximately 4-hourly intervals omitting the night-time dose. Treatment should continue for 5 days, but in severe initial infections, treatment may have to be extended. In severely immune-compromised patients (e.g. after marrow transplant) or patients with impaired absorption from the gut, the dose can be doubled to 400 mg or alternatively intravenous dosing could be considered. Dosing should begin as early as possible after the start of an infection; for recurrent episodes this should preferably be during the prodromal period or when lesions first appear.
Dosage for suppression of herpes simplex in adults: For suppression of herpes simplex infections in immune-competent patients, 200 mg Acyclovir should be taken 4 times daily at approximately 6-hourly intervals. Many patients may be conveniently managed on a regimen of 400 mg Acyclovir taken twice daily at approximately 12-hourly intervals.
Dosage titration down to 200 mg Acyclovir taken thrice daily at approximately 8-hourly intervals or even twice daily at approximately 12-hourly intervals may prove effective. Some patients may experience break-through infections on total daily doses of 800 mg Acyclovir, Therapy should be interrupted periodically at intervals of 6~12 months, in order to observe possible changes in the natural history of the disease.
Dosage for prophylaxis of herpes simplex in adults: For prophylaxis of herpes simplex infections in immune-compromised patients, 200 mg Acyclovir should be taken 4 times daily at approximately 6 hourly intervals.
In severely immune-compromised patients (e.g. after marrow transplant) or in patients with impaired absorption from the gut, the dose can be doubled to 400 mg or alternatively intravenous dosing could be considered.
The duration of prophylactic administration is determined by the duration of the period at risk.
Dosage for treatments of herpes zoster in adults: For treatment of herpes zoster infections, 800 mg Acyclovir should be taken 5 times daily at approximately 4-hourly intervals, omitting the night-time dose, Treatment should continue for 7 days. In severely immune-compromised patients (e.g. after marrow transplant) or in patients with impaired absorption from the gut, consideration should be given to intravenous dosing. Dosing should begin as early as possible after the start of an infection; treatment yields better results if initiated as soon as possible after onset of the rash.
Dosage in children: For treatment of herpes simplex infections, and for prophylactics of herpes simplex infections in the immune-compromised, children over the age of 2 years should be given adult dosage and children below the age of 2 years should be given half the adult dose.
No specific data are available on the suppression of herpes simplex infections or the treatment of herpes zoster infections in immune-competent children.
Dosage in the elderly: In the elderly, total Acyclovir body clearance declines in parallel with creatinine clearance. Adequate hydration of elderly patients taking high oral doses of Acyclovir should be maintained. Special attention should be given to dosage reduction in elderly patients with impaired renal function.
Dosage in renal impairment: In the management of herpes simplex infections in patients with impaired renal function, the recommended oral dosage will not lead to accumulation of acyclovir above levels that have been established safe by intravenous infusions. However, for patients with severe renal impairment (creatinine clearance less than 10 ml/minute) an adjustment of dosage to 200 mg twice daily at approximately 12-hourly intervals is recommended.
In the treatment of herpes zoster infections, it is recommended to adjust the dosage 800 mg twice daily at approximately 12-hourly intervals for patients with severe renal impairment (creatinine clearance less than 10 ml/minute), and to 800 mg 3 times daily at intervals of approximately 6 hours for patients with moderate renal impairment (creatinine clearance in the range 10~25 ml/minute).
Route of Administration: Oral.
Cream: Topical application.
Adults, children and geriatric: Acylete Cream should be applied five times daily at approximately 4-hourly intervals omitting the night-time dose. Acylete Cream should be applied to the lesions or impending lesions as early as possible after the start of an infection. It is particularly important to start treatment of recurrent episodes during the prodromal period or when the lesions first appear. Treatment should be continued for 5 days. If healing has not occurred, treatment may be continued for up to 10 days.