Provagin

Provagin

metronidazole + nystatin

Manufacturer:

Meprofarm

Marketer:

Meprofarm
Concise Prescribing Info
Contents
Metronidazole 500 mg, nystatin 100,000 IU
Indications/Uses
Vaginitis due to Trichomonas vaginalis & Candida albicans.
Dosage/Direction for Use
Insert 1 ovule daily into the vag before bedtime for 7-10 days.
Contraindications
Hypersensitivity. 1st trimester of pregnancy.
Special Precautions
Monitor total & differential leukocyte counts in patients w/ blood dyscrasias before & after therapy. Reduce or discontinue use if irritation occurs. Avoid vag intercourse & use of vag douche during therapy. Patients w/ hepatic encephalopathy. Peripheral neuropathy & epilepsy may occur due to high dose or long-term use. Pregnancy & lactation. Elderly.
Adverse Reactions
Hypersensitivity. Dryness & burning sensation in vag; itches, urticaria, pruritus, erythema multiforme, angioedema & anaphylactic reaction; nausea, metal taste accompanied by vomiting & anorexia; diarrhea, dry mouth, furred tongue, glossitis, stomatitis; colitis pseudomembrane; peripheral neuropathy; leukopenia & thrombocytopenia.
Drug Interactions
Prolonged prothrombin time or blood clotting w/ anticoagulants. Disulfiram-like reaction w/ alcohol. Acute psychosis & confusion may occur w/ disulfiram. Increased serum conc of lithium.
MIMS Class
Preparations for Vaginal Conditions
ATC Classification
G01AA51 - nystatin, combinations ; Belongs to the class of antibiotics. Used in the treatment of gynecological infections.
Presentation/Packing
Form
Provagin ovule
Packing/Price
10's (Rp130,000/pak)
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