Atenolol is sparingly soluble in water.
Pharmacology: Atenolol is a β-adrenergic-blocking agent used in the treatment of hypertension.
Internolol is cardioselective, having β1-blocking effect, resulting in decreased cardiac rate, contractility and renin secretion.
Pharmacokinetics: Since Internolol has a long duration of action with a long plasma half-life, it may be given once daily. It is primarily excreted renally, therefore, the dose should be controlled in renally impaired patients.
Hypertension; angina pectoris; tachycardia; prevention of acute myocardial infarction.
Adults: Antiangina and Antiarrhythmia: 50 mg daily, may be increased to 100-200 mg daily.
Renal Function Impairment (creatinine clearance <15 mL/min/1.73 m2): Maximum Dose: 50 mg daily.
Antihypertension: 25 mg daily, dose may be increased to 50-100 mg daily.
Cardiac weakness, 2nd- and 3rd-degree AV block, sinus bradycardia, renal dysfunction, hypotension, asthma, peripheral vascular disease, after long fasting.
Caution should be observed in patients with mild peripheral vascular circulation disorder. In patients with mild cardiac disorder and mild conductive cardiac disorder (1st-degree), a β-blocker may be given with ISA.
Additive effect manifesting atrioventricular (AV) conductive depression may occur if β-blocker is used concomitantly with digitalis, which may lead to AV dissociation and cardiac arrest.
Rebound phenomenon may occur if β-blocker is suddenly discontinued and may worsen angina and myocardium infarction. Tapering of dose should be done if to discontinue β-blocker.
Stop administration if allergic reactions (rash, fever, purpura), renal and hepatic dysfunction occur, and during major surgery and in diabetic mellitus patients.
Bronchospasm may occur in the elderly.
Use in pregnancy & lactation: Internolol must not be given during pregnancy and lactation.
Use in children: Internolol is not recommended for children.
Internolol must not be given during pregnancy and lactation.
Heart failure, bradycardia, bronchospasm, peripheral circulatory disturbances, hypoglycaemia and AV block may occur.
Other adverse reactions are fatigue, depression, decreased concentration, nausea, vomiting, mild diarrhoea, constipation, rash, paraesthesia and agranulocytosis.
Atenolol may increase the hypoglycaemic effect of insulin and other antidiabetic drugs, cardiodepressant effect of calcium antagonists, antiarrhythmias and anaesthetic drugs.
Combined use of β-blocker with calcium antagonists, nitrates, hypnotics, nueroleptics and diuretics may cause a hypotensive effect.
Combination with clonidine may cause hypertension if suddenly withdrawn.
Store at room temperature, in a dry place. Protect from sunlight.
C07AB03 - atenolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Internolol tab 50 mg
3 × 10's
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