Caution should be observed in patients with mild peripheral vascular circulation disorder. In patients with mild cardiac disorder and mild conductive cardiac disorder (1st-degree), a β-blocker may be given with ISA.
Additive effect manifesting atrioventricular (AV) conductive depression may occur if β-blocker is used concomitantly with digitalis, which may lead to AV dissociation and cardiac arrest.
Rebound phenomenon may occur if β-blocker is suddenly discontinued and may worsen angina and myocardium infarction. Tapering of dose should be done if to discontinue β-blocker.
Stop administration if allergic reactions (rash, fever, purpura), renal and hepatic dysfunction occur, and during major surgery and in diabetic mellitus patients.
Bronchospasm may occur in the elderly.
Use in pregnancy & lactation: Internolol must not be given during pregnancy and lactation.
Use in children: Internolol is not recommended for children.