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Gynprogest may interfere with the effects of bromocriptine and may raise the plasma concentration of cyclosporine. Gynprogest may affect the results of laboratory tests of hepatic and/or endocrine functions.
Metabolism of Gynprogest is accelerated by rifampicin an antibacterial agent.
The metabolism of progesterone by human liver microsomes was inhibited by ketoconazole (IC50 <0.1 μm). Ketoconazole is a known inhibitor of cytochrome P450 3A4. Therefore ketoconazole may increase the bioavailability of progesterone.
