Shortening of the cycle or breakthrough bleeding may occur if the treatment sequence is initiated too early particularly before cycle day 1. If this occurs, the dose of Gynprogest can be reduced and taken at bedtime from day 1 to day 26 of each therapeutic cycle.
Acne, urticaria, rashes, fluid retention, weight changes, gastro-intestinal disturbances, changes in libido, breast discomfort, premenstrual symptoms, menstrual disturbances; also chloasma, depression, pyrexia, insomnia, alopecia, hirsutism; rarely jaundice. Venous thromboembolism, i.e. deep leg or pelvic venous thrombosis and pulmonary embolism, is more frequent among hormone replacement therapy users than among non-users.
After vaginal administration, local irritation may occur (due to the presence of soya lecithin, peanut oil). The following effects have been reported in associated with soft capsules administered via the oral route.
Common undesirable effects: altered menstrual cycles, amenorrhea, intermenstrual bleeding, and headaches.
Uncommon undesirable effects: drowsiness, transient dizziness, cholestatic jaundice, pruritus, gastrointestinal disorder.
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