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Innohep should be given with caution to patients with hepatic insufficiency. Precaution is recommended in the treatment of patients with severe renal impairment (creatinine clearance <30 ml/min).
Precaution is recommended in the treatment of elderly patients with renal impairment. Renal function should be assessed and in patients with severe renal impairment (creatinine clearance <30 ml/min), monitoring of anti-factor Xa activity should be considered.
Innohep should not be administered by intramuscular injection due to risk of local haematoma formation.
Patients receiving Innohep concurrently with spinal or epidural anaesthesia should be closely monitored for signs or symptoms of neurological injury.
