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An overdose of Innohep may be complicated by haemorrhage. At recommended doses there should be no need for an antidote, but in the event of accidental administration of an overdose, the effect of Innohep can be reversed by intravenous administration of 1% protamine sulphate solution.
The dose of protamine sulphate required per neutralization should be accurately determined by titrating with the plasma of the patient. As a rule, 1 mg of protamine sulphate neutralizes the effect of 100 IU anti-Xa of tinzaparin.
