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Known hypersensitivity to any of the constituents.
The 20,000 IU anti-Xa/ml formulation of Innohep contains sodium metabisulphite, which may cause allergic reactions, including anaphylaxis in predisposed patients. In the remaining formulations without sulphite, this risk does not exist.
Other contraindications are: Generalized or local haemorrhagic tendency; Uncontrolled severe hypertension; Acute cerebral insults; Septic endocarditis.
For vials only: Innohep vials contain 10 mg/ml of the preservative benzyl alcohol. These formulations must not be given to premature babies and neonates due to the risk of gasping syndrome.
