Treatment of DVT & PE 175 anti-Xa IU/kg SC once daily.
Thromboprophylaxis in patients w/ moderate risk of thrombosis (general surgery) 3,500 anti-Xa IU SC 2 hr before surgery & 3,500 anti-Xa IU once daily for 7-10 days post-op.
Thromboprophylaxis in patients w/ high risk of thrombosis (eg, total hip replacement) 4,500 anti-Xa IU SC 12 hr before surgery, or 50 anti-Xa IU/kg SC 2 hr before surgery & then once daily until the patient has been mobilized.
Short-term haemodialysis (<4 hr) Bolus dose of 2,000-2,500 anti-Xa IU into the arterial side of the dialyser (or IV) at the beginning of dialysis.
Long-term haemodialysis (>4 hr) Bolus dose of 2,500 anti-Xa IU into the arterial side of the dialyser (or IV) at the beginning of dialysis, followed by an infusion of 750 anti-Xa IU/hr. If required, increase or decrease bolus dose in steps of 250-500 anti-Xa IU until satisfactory response is obtained.
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