Amedin Special Precautions

As with all calcium antagonists, amlodipine's half-life is prolonged in patients with impaired liver function and dosage recommendations have not been established. Amedin should therefore be administered with caution in these patients. There are no data to support the use of Amedin alone, during or within 1 month of myocardial infarction. The safety and efficacy of Amedin in hypertensive crisis has not been established.
Effects on the Ability to Drive or Operate Machinery: Clinical experience with Amedin indicates that therapy is unlikely to impair a patient's ability to drive or use machinery.
Use in pregnancy & lactation: Although some dihydropyridine compounds have been found to be teratogenic in animals, data in rat and rabbit for amlodipine provide no evidence for a teratogenic effect. There is, however, no clinical experience with Amedin in pregnancy or lactation. Accordingly, Amedin should not be administered during pregnancy, or lactation, or to women of childbearing potential unless effective contraception is used.