Amedin Drug Interactions

Amedin has been safely administered with thiazide diuretics, α-blockers, β-blockers, ACE inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, nonsteroidal anti-inflammatory drugs, antibiotics and oral hypoglycaemic drugs.
Pharmacokinetic studies with cyclosporin have demonstrated that amlodipine does not significantly alter the pharmacokinetics of cyclosporin. Special studies have indicated that the co-administration of Amedin with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers and that the co-administration of cimetidine did not alter the pharmacokinetics of amlodipine. In healthy male volunteers, the co-administration of Amedin does not significantly alter the effect of warfarin on prothrombin response time.
In vitro data from studies with human plasma indicate that amlodipine has no effect on protein binding of digoxin, phenytoin, warfarin or indomethacin.
Grapefruit juice may interact with Amedin to increase the plasma concentration. However, this increase is too small to significantly alter blood pressure or heart rate.