Đăng xuất
TIENAM (imipenem and cilastatin sodium, MSD) is a broad spectrum beta-lactam antibiotic supplied as a formulation for intravenous infusion only. TIENAM consists of two components: imipenem, the first of a new class of beta-lactam antibiotics, the thienamycins; and cilastatin sodium, a specific enzyme inhibitor that blocks the metabolism of imipenem in the kidney, and substantially increases the concentration of intact imipenem in the urinary tract. Imipenem and cilastatin sodium are present in TIENAM in a 1:1 ratio by weight.
The thienamycin class of antibiotics, to which imipenem belongs, is characterized by a broad spectrum of bactericidal activity.
TIENAM for intravenous infusion is supplied as a sterile powder in vials containing 500mg imipenem equivalent and 500mg cilastatin equivalent.
In addition, TIENAM contains Sterile Sodium Bicarbonate as inactive ingredient.
