Voluven Dosage/Direction for Use

Voluven is administered by intravenous infusion only.
The daily dose and rate of infusion depend on the patient's blood loss, on the maintenance or restoration of haemodynamics and on the haemodilution (dilution effect). Use at the lowest effective dose for the shortest period of time. Should not be used for more than 24 hours.
The initial 10-20 ml should be infused slowly, keeping the patient under close observation (due to possible anaphylactic/anaphylactoid reactions).
Adult dose: Up to 50 ml of Voluven per kg of body weight per day (equivalent to 3.0 g hydroxyethyl starch and 7.7 mEq sodium per kg of body weight). This dose is equivalent to 3,500 ml Voluven for a 70 kg patient.
Paediatric dose: The dosage in children should be adapted to the individual patient colloid needs, taking into account basic disease, haemodynamics, and hydration status.
In 41 newborns to infants (< 2 years), a mean dose of 16±9 ml/kg was administered. In 31 children from 2 - 12 years of age a mean dose of 36 ± 11 ml/kg was administered. The dose in adolescents > 12 is the same as the adult dose.