Valovir-500 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Valaciclovir HCl

Indications/Uses

Herpes zoster (shingles). Treatment or suppression of genital herpes in immunocompetent individuals w/ & for suppression of recurrent genital herpes in HIV-infected individuals. Cold sores (Herpes labialis).

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Dosage/Direction for Use

Herpes zoster 1 g tid for 7 days. Genital herpes Initial episodes: 1 g bid for 10 days. Recurrent episodes: 500 mg bid for 3 days. Suppressive therapy: Patients w/ healthy immune function 1 g once daily; w/ history of ≤9 recurrences per yr & alternative dosage 500 mg once daily. Chronic suppressive therapy of recurrent genital herpes in HIV-infected patients w/ CD4 cell count at least 100 cells/mm³ 500 mg bid. Reduction of transmission: Patients w/ history of ≤9 recurrences per yr 500 mg once daily for source partner. Cold sores (Herpes labialis) 2 g bid, taken about 12 hr apart.

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Overdosage

View Valovir-500 overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity or intolerance to valaciclovir, aciclovir.

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Special Precautions

TTP/haemolytic uremic syndrome (HUS) in patients w/ advanced HIV infection & in allogenic bone marrow or renal transplant recipients receiving high dosage (8 g daily). Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

HTN, tachycardia; depression, dizziness, headache, aggressive behaviour, agitation, ataxia, coma, confusion, decreased consciousness, dysarthria, encephalopathy, mania, psychosis including, auditory & visual hallucinations, seizures, tremors; rash, alopecia, erythema multiforme, rashes including, photosensitivity; abdominal pain, nausea, vomiting, diarrhea; aplastic anemia, leukocytoclastic vasculitis, thrombocytopenia, TTP/HUS; hepatic, liver enzyme abnormalities; acute hypersensitivity reactions including anaphylaxis, angioedema, dyspnea, pruritus & urticaria; visual abnormalities; elevated creatinine, renal failure; facial edema.

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Drug Interactions

Consider dosage adjustment in concomitant use w/ Al- or Mg-containing antacids & digoxin. Increased peak plasma conc & AUC w/ cimetidine & probenecid.

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Storage

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Description

View Valovir-500 description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antivirals

ATC Classification

J05AB11 - valaciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.

Thai FDA Category

Presentation/Packing

Form

Valovir-500 FC tab 500 mg

Packing/Price

5 × 10's

Valovir-500

valaciclovir

Manufacturer:

Hetero Labs

Distributor:

Osoth Interlab

Marketer:

Osoth Interlab