Valovir-500 Drug Interactions

Antacids: Concomitant use of Valaciclovir and aluminium- or magnesium-containing antacids does not affect the pharmacokinetics of Aciclovir dosage adjustments are necessary.
Cimetidine: Concomitant use of Valaciclovir and Cimetidine may increase peak plasma concentrations and AUC of Aciclovir. This pharmacokinetics interaction is not considered clinically important in patients with normal renal function; no dosage adjustment are necessary in these patients.
Probenecid: Concomitant use of Valaciclovir and Probenecid may increase peak plasma concentrations and AUC of Aciclovir. This pharmacokinetics interaction is not considered clinically important in patients with normal renal function; no dosage adjustment are necessary in these patients.
Digoxin: Concomitant use of Valaciclovir and Digoxin does not affect the pharmacokinetics of Aciclovir or Digoxin dosage adjustment are necessary.
Thiazide diuretics: Concomitant use of Valaciclovir and Thiazide diuretics does not affect the pharmacokinetics of Aciclovir; no dosage adjustments are necessary.