RA, AS 90 mg once daily. Acute pain 90 mg during acute symptomatic period. Post-op dental pain 90 mg once daily for up to 3 days. Post-op gynecological pain 90 mg once daily for up to 5 days. Administer initial dose shortly before surgery. May be increased to max 120 mg once daily. Mild hepatic insufficiency (Child-Pugh score 5-6) Max: 60 mg once daily, moderate hepatic insufficiency (Child-Pugh score 7-9) Max: 60 mg every other day. May consider 30 mg once daily.
View Torcozia overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
History of hypersensitivity to etoricoxib; allergic-type reaction (eg, bronchospasm, acute rhinitis, nasal polyps, angioedema, urticaria) to aspirin or other NSAIDS. CHF (NYHA class II-IV); established ischemic heart disease, peripheral artery disease &/or cerebrovascular disease (including those who have recently undergone CABG surgery or angioplasty); persistent uncontrolled HTN. Active peptic ulceration or GI bleeding; inflammatory bowel disease. Severe hepatic dysfunction (Child-Pugh score >9) & severe renal impairment (CrCl <30 mL/min). Pregnancy & lactation. Childn <16 yr.
Patients w/ significant risk factors for CV disease eg, HTN, hyperlipidaemia & DM. Avoid in patients w/ history of mild allergic phenomena related to ingestion of other NSAIDs eg, rash; conditions predisposing to GI events (eg, history of peptic ulcer, upper GI disease, ulcerative colitis, smoking, advancing age, concurrent use of aspirin or corticosteroids, alcohol abuse, stress); bleeding disorders (potential exacerbation).
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