Adult Postherpetic neuralgia 150-300 mg daily in 2 or 3 divided doses. Initially 150 mg daily (75 mg bid or 50 mg tid). May be increased to 300 mg daily w/in 1 wk.
Pain associated w/ diabetic peripheral neuropathy Initially 150 mg daily in 3 divided doses. May be increased w/in 1 wk to max of 300 mg daily in 3 divided doses.
Fibromyalgia 300-450 mg daily. Initially 150 mg daily (75 mg bid). May be increased to 300 mg daily (150 mg bid) w/in 1 wk.
Adjunctive therapy in management of partial seizures 150-600 mg daily in 2 or 3 divided doses. Initially 75 mg bid or 50 mg tid (Max: 150 mg daily). May be increased to max of 600 mg daily.
Renal impairment w/ CrCl 30-60 mL/min 150 mg normal renal function daily dose: Reduce to 75 mg in 2-3 divided doses, 300 mg: Reduce to 150 mg in 2-3 divided doses, 450 mg: Reduce to 225 mg in 2-3 divided doses, 600 mg: Reduce to 300 mg in 2-3 divided doses;
15-30 mL/min 150 mg normal renal function daily dose: Reduce to 25-50 mg in 1-2 divided doses, 300 mg: Reduce to 75 mg in 1-2 divided doses, 450 mg: Reduce to 100-150 mg in 1-2 divided doses, 600 mg: Reduce to 150 mg in 1-2 divided doses;
<15 mL/min 150 mg normal renal function daily dose: Reduce to 25 mg daily, 300 mg: Reduce to 25-50 mg daily, 450 mg: Reduce to 50-75 mg daily, 600 mg: Reduce to 75 mg daily.
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