Pobalin Dosage/Direction for Use

Pregabalin capsules are administered orally without regard to meals. If pregabalin is discontinued, dosage should be tapered gradually over at least 1 week.
Neuropathic Pain: Postherpetic Neuralgia: For the management of postherpetic neuralgia (PHN) in adults, the recommended dosage of pregabalin is 150-300 mg daily administered in 2 or 3 divided doses. Pregabalin therapy generally is initiated at a dosage of 150 mg daily (75 mg twice daily or 50 mg 3 times daily); dosage may be increased to 300 mg daily within 1 week based on efficacy and tolerability.
Diabetic Neuropathy: For the management of pain associated with diabetic peripheral neuropathy (DPN) in adults, the initial dosage of pregabalin is 150 mg daily administered in 3 divided doses; dosage may be increased within 1 week based on efficacy and tolerability to the maximum recommended dosage of 300 mg daily administered in 3 divided doses.
Seizure Disorder: For adjunctive therapy in the management of partial seizures in adults, the effective dosage of pregabalin is 150-600 mg daily administered in 2 or 3 divided doses. Pregabalin therapy generally is initiated at a dosage of 75 mg twice daily or 50 mg 3 times daily (initial dosage not to exceed 150 mg daily); based on individual patient response and tolerability, dosage may be increased to a maximum dosage of 600 mg daily.
Fibromyalgia: For the management of fibromyalgia in adults, the recommended dosage of pregabalin is 300-450 mg daily. Pregabalin therapy generally is initiated at a dosage of 150 mg daily (75 mg twice daily); dosage may be increased to 300 mg daily (150 mg twice daily) within 1 week based on efficacy and tolerability.
Dosage adjustment in renal impairment: Renal function may be estimated using the Cockcroft-Gault formula. Then determine recommended dosage regimen based on the indication-specific total daily dose for normal renal function (CrCl ≥ 60 mL/minute). For example, if the indication-specific daily dose is 450 mg daily for normal renal function, the daily dose should be reduced to 225 mg daily (in 2-3 divided doses) for a creatinine clearance of 30-60 mL/minute (see table).

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