Angina pectoris in patients who have not responded to recommended doses of organic nitrates &/or β-blockers. CHF associated w/ acute MI. Control of BP in perioperative HTN. Production of controlled hypotension during surgical procedures.
IV infusion Initially 5 mcg/min w/ subsequent titration to adjust the dose w/ increments of 5 mcg/min every 3-5 min. If no response at 20 mcg/min, increments of 10 & later 20 mcg/min.
Not to be administered via direct IV; intracoronary inj. Not to be admixed w/ other drugs. Not to be used >3 successive days. Patients w/ malnutrition, hypothyroidism, severe hypothermia, close angle glaucoma; normal or low pulmonary capillary wedge pressure. Lactic acidosis. Avoid prolonged use. Severe hepatic & renal impairment. Pregnancy & lactation. Childn.
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