Memotin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Memantine HCl

Indications/Uses

Moderate to severe dementia of Alzheimer's type.

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Dosage/Direction for Use

Adult Initially 5 mg once daily. Following initiation of therapy, increase to 10 mg daily (5 mg bid), subsequently increase to 15 mg daily (5 mg & 10 mg as separate doses), then 20 mg daily (10 mg bid). Recommended target dose: 20 mg daily in 2 divided doses (10 mg bid). Severe renal impairment (CrCl 5-29 mL/min) 5 mg bid.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity.

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Special Precautions

Seizures. Conditions that increase urinary pH eg, dietary changes (from a high protein to vegetarian diet); renal tubular acidosis; severe UTI. Concomitant use of urine alkalizers eg, carbonic anhydrase inhibitors, Na bicarbonate. Hepatic impairment. Severe renal impairment. Pregnancy & lactation. Childn. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Confusion, dizziness, fatigue, hallucination, headache, somnolence, agitation, anxiety, depression, abnormal gait, insomnia; constipation, vomiting, diarrhea, nausea; coughing, dyspnea, bronchitis, URTI; back pain, HTN, pain, anorexia, arthralgia, fall, inflicted injury, flu-like symptoms, peripheral edema; urinary incontinence, UTI.

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Drug Interactions

Minimal inhibition of CYP isoenzymes 1A2, 2A6, 2C9, 2D6, 2E1, or 3A4. Altered plasma conc w/ drugs secreted by the same renal cationic system eg, cimetidine, hydrochlorothiazide, metformin, nicotine, quinidine, ranitidine, triamterene. Decreased clearance w/ agents that increase urine pH eg, carbonic anhydrase inhibitors, Na bicarbonate.

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Storage

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Description

View Memotin description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Neurodegenerative Disease Drugs

ATC Classification

N06DX01 - memantine ; Belongs to the class of other anti-dementia drugs.

Thai FDA Category

Presentation/Packing

Form

Memotin film-coated tab 10 mg

Packing/Price

2 × 14's

Memotin

memantine

Manufacturer:

Atlantic Lab

Distributor:

Atlantic Pharma

Marketer:

Atlantic Pharma