Memotin Dosage/Direction for Use

Recommended Dose: Importance of instructing caregiver regarding proper administration (twice daily for dosages exceeding 5 mg daily) and dosage escalation (minimal interval of 1 week between dosage increases).
The recommended initial adult dosage of memantine hydrochloride is 5 mg once daily. The dosage of memantine hydrochloride shown to be effective in clinical trials and the recommended target dosage is 20 mg daily, given in 2 divided doses (10 mg twice daily). Dosage should be increased to the target dosage in increments of 5 mg daily at intervals of not less than 1 week. Following initiation of therapy at a dosage of 5 mg once daily, dosage should be increased to 10 mg daily (5 mg twice daily), with subsequent increase to 15 mg daily (5 mg and 10 mg as separate doses) and then to 20 mg daily (10 mg twice daily).
Special populations: No dosage adjustment is needed in patients with mild to moderate renal impairment. However, in patients wit severe renal impairment (i.e., creatinine clearance of 5-29 mL/minute), a target dosage of 5 mg twice daily is recommended. Creatinine clearance may be estimated using the following formulas: See equation.

Click on icon to see table/diagram/image

Where age is in years, weight is in kg, and serum creatinine is in mg/dL.
Mode of Administration: Memantine hydrochloride is administered orally without regard to meals.