Intoricoxib Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Etoricoxib

Indications/Uses

Ankylosing spondylitis, RA, OA, acute gouty arthritis. Pain & inflammation associated w/ dental surgery.

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Dosage/Direction for Use

Adult Ankylosing spondylitis, RA 60 mg once daily, may increase to 90 mg once daily. May reduce to 60 mg once daily once patient is clinically stable. OA 30 mg once daily, may increase to 60 mg once daily. Acute gouty arthritis 120 mg once daily. Max duration: 8 days. Pain & inflammation associated w/ dental surgery 90 mg once daily. Max duration: 3 days. Moderate hepatic impairment (Child-Pugh score 7-9) Max: 30 mg once daily; mild hepatic impairment (Child-Pugh score 5-6) Max: 60 mg once daily.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Patient w/ active peptic ulceration or GI bleeding, inflammatory bowel disease, CHF (NYHA II-IV), uncontrolled HTN or w/ persistently high BP (>140/90 mmHg), ischaemic heart disease, peripheral arterial & cerebrovascular disease. History of bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria or allergic-type reactions after taking aspirin, NSAIDs including COX-2 inhibitors. Renal (CrCl <30 mL/min) & severe hepatic (Child-Pugh ≥10) impairment. Pregnancy. Childn & adolescent <16 yr.

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Special Precautions

History of GI disease (eg, ulceration, bleeding); cardiac failure, left ventricular dysfunction, preexisting oedema, dehydration. Risk factors for CV events (eg, hyperlipidaemia, HTN, DM, smoking); uncompensated heart failure, cirrhosis. Mild to moderate hepatic impairment. Oligohydramnios & fetal renal impairment in NSAIDS use at >20 wk gestation; fetal ductus arteriosus premature closure & persistent pulmonary HTN at >30 wk gestation. Avoid NSAID at 30 wk & later gestation. Lowest effective dose for shortest duration if NSAID is needed during 20-30 wk gestation. Lactation. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Fluid retention, oedema, HTN, increased ALT or AST, hypersensitivity reactions eg, anaphylaxis, angioedema; palpitations, arrhythmia; abdominal pain, constipation, flatulence, gastritis, heartburn, diarrhoea, dyspepsia, nausea, vomiting, oesophagitis, oral ulcer; asthenia, flu-like disease; alveolar osteitis; headache; bronchospasm. GI perforations, ulcers or bleedings, exfoliative dermatitis, SJS, TEN.

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Drug Interactions

Increased INR w/ anticoagulants eg, warfarin. Decreased effect of diuretics & antihypertensive agents. Deteriorated renal function w/ ACE inhibitor or AIIA. Increased rate of GI ulceration w/ low dose ASA. Increased plasma conc of ethinylestradiol, lithium, MTX, & other drugs metabolised by human sulfotransferases eg, oral salbutamol, minoxidil. Decreased plasma conc w/ rifampicin.

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Storage

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Description

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Action

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MIMS Class

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

ATC Classification

M01AH05 - etoricoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.

Thai FDA Category

Presentation/Packing

Form

Intoricoxib FC tab 90 mg

Packing/Price

30's;7's

Intoricoxib

etoricoxib

Manufacturer:

Intega

Distributor:

Pacific Healthcare

Marketer:

Pacific Healthcare