Use in Pregnancy: PO: Z (NSAIDs use in >20 weeks gestation may cause oligohydramnios and fetal renal impairment. Fetal ductus arteriosus premature closure and persistent pulmonary hypertension may occur >30 weeks gestation. Avoid NSAIDs 30 weeks and later. If an NSAID is needed during 20-30 weeks, use lowest effective dose for shortest duration.).