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Dosage of iron sucrose in excess of iron need may lead to accumulation of iron in storage sites leading to hemosiderosis. Periodic monitoring of iron parameters such as serum ferritin and transferrin saturation may assist in recognizing iron accumulation. Iron sucrose should not be administered to patients with iron overload and should be discontinued when serum ferritin levels equal to avoid iron overload where anemia unresponsive treatment has been incorrectly diagnosed as iron deficiency anemia.
Symptoms associated with overdosage or infusing iron sucrose too rapidly included hypotension, headache, vomiting nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema, and cardiovascular collapse, Most symptoms have been successfully treated with IV fluids, hydrocortisone, and/or antihistamines. Infusing the solution as recommended or at a slower rate may also alleviate symptoms.
