Encifer Dosage/Direction for Use

The dosage of iron sucrose is expressed in terms of mg elemental iron. Each mL contains 20 mg of elemental iron.
The recommended dosage of iron sucrose for the repletion treatment of iron deficiency in hemodialysis patients is 5 mL of iron sucrose (100 mg of elemental iron) delivered intravenously during the dialysis session. Most patients will require a minimum cumulative dose of 1000 mg of elemental iron, administered over 10 sequential dialysis sessions, to achieve a favorable hemoglobin or hematocrit response. Patients may continue to require therapy with Iron sucrose or other intravenous iron preparations at the lowest dose necessary to maintain target levels of hemoglobin, hematocrit and laboratory parameters of iron storage within acceptable limits.
Recommended Dosage: Adults: 100 mg iron administered one to three times per week to a total dose of 1000 mg in 10 doses, repeat if needed. Frequency of dosing should be not more than three times weekly. Patients may continue to require therapy with intravenous Iron at the lowest dose necessary to maintain levels of hemoglobin, hematocrit and laboratory parameters of iron storage within acceptable limits.
Administration: Iron sucrose must only be administered intravenously either by slow injection or by infusion.
Slow intravenous injection: In chronic renal failure (CRF) patients, Iron sucrose may be administered undiluted by slow intravenous injection into the dialysis line at a rate of 1 mL (20 mg iron) solution per minute (i.e., 5 minutes per ampoule) not exceeding one ampoule iron sucrose (100 mg iron) per injection. Discard any unused portion.
Infusion: Iron sucrose may also be administered by infusion (into the dialysis line for hemodialysis patients). The content of each vial must be diluted exclusively in a maximum of 100 mL of 0.9% NaCl, immediately prior to infusion.
The solution should be infused at a rate of 100 mg of iron over a period of at least 15 minutes. Unused diluted solution should be discarded.
NOTE: Do not mix Encifer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.