Sign Out
There is no experience in the use of Dexdor for more than 14 days. The use of Dexdor for longer than this period should be regularly reassessed.
Dexdor should be administered using a controlled infusion device.
Dosage Information: See Table 8.
Click on icon to see table/diagram/imageDosage Adjustment: Due to possible pharmacodynamic interactions, a reduction in dosage of Dexdor or other concomitant anesthetics, sedatives, hypnotics or opioids may be required when co-administered. [see Anesthetics, Sedatives, Hypnotics, Opioids under Interactions].
Dosage reductions may need to be considered for patients with renal or hepatic impairment, and geriatric patients [see Hepatic Impairment under Precautions and PHARMACOLOGY: Pharmacokinetics under Actions].
Preparation of Solution: Dexdor can be diluted in glucose 50 mg/ml (5%), Ringers, mannitol or sodium chloride 9 mg/ml (0.9%) solution for injection to achieve the required concentration of either 4 micrograms/ml or 8 micrograms/ml prior to administration. See tabulated form the volumes needed to prepare the infusion as follows. (See Table 9.)
Click on icon to see table/diagram/imageThe solution should be shaken gently to mix well.
Strict aseptic technique must always be maintained during handling of Dexdor.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Administration with Other Fluids: Dexdor infusion should not be co-administered through the same intravenous catheter with blood or plasma because physical compatibility has not been established.
Dexdor has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam.
Dexdor has been shown to be compatible when administered with the following intravenous fluids: 0.9% sodium chloride in water, 5% dextrose in water, 20% mannitol, lactated ringer's solution, 100 mg/mL magnesium sulfate solution and 0.3% potassium chloride solution.
