Decreased efficacy & increased breakthrough bleeding w/ rifampin, barbiturates, bosentan, carbamazepine, dexamethasone, griseofulvin, phenylbutazone, phenytoin, felbamate, oxcarbazepine, rifabutin, modafinil, topiramate, primidone. Altered AUC w/ HIV PIs or NNRTIs. Decreased efficacy w/ anti-infective agents eg, ampicillin, chloramphenicol, neomycin, nitrofurantoin, penicillin V, sulfonamides, tetracyclines; St. John's wort. Increased plasma conc w/ fluconazole, itraconazole, ketoconazole, atorvastatin, ascorbic acid, acetaminophen. Increased metabolism of benzodiazepines eg, lorazepam, oxazepam, temazepam. Increased AUC of metoprolol. Enhanced anti-inflammatory effect of hydrocortisone. Increased plasma conc of prednisolone; cyclosporine & theophylline.
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