IM/IV Duration of therapy: Continue treatment for min of 48-72 hr in general. Min of 10 days for infections caused by group A β-hemolytic Strep.
Adult & childn weighing ≥50 kg Max: 12 g daily.
Adult Gonococcal urethritis/cervicitis 0.5 g IM as single dose.
Rectal gonorrhea 1 g IM as single dose in men, 0.5 g IM as single dose in women.
Moderate to severe infections 1-2 g every 8 hr.
More severe infections needing higher dose of antibiotics eg, septicemia 2 g IV every 6-8 hr.
Life-threatening infections 2 g IV every 4 hr up to 12 g daily.
Perioperative prophylaxis Recommended dose: Administer single 1 g 30-90 min prior to surgery.
Cesarean section 1st dose: Administer 1 g IV as soon as the umbilical cord is clamped. 2nd & 3rd dose: Give 1 g at 6 & 12 hr after 1st dose.
Uncomplicated infections 1 g every 12 hr.
Childn 1 mth to 12 yr weighing <50 kg 50-180 mg/kg daily in 4-6 divided doses,
1-4 wk 50 mg/kg IV every 8 hr,
0-1 wk 50 mg/kg IV every 12 hr.
Renal impairment w/ CrCl 10-50 mL/min Give doses every 12-24 hr,
CrCl <10 mL/min Give doses every 24 hr.
Adult receiving continuous renal replacement therapy 1 g every 12 hr,
continuous venovenous hemofiltration 1-2 g IV every 8-12 hr,
continuous venovenous hemodialysis 1-2 g IV every 8 hr,
continuous venovenous hemodiafiltration 1-2 g IV every 6-8 hr.
Adult receiving intermittent hemodialysis 0.5-2 g supplement after dialysis. Alternatively, 1-2 g IV every 24 hr after dialysis on dialysis days.
Continuous ambulatory peritoneal dialysis 0.5-1 g every 24 hr.
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