Sign Out
The acute toxicity of cefotaxime was evaluated in neonatal and adult mice and rats. Significant mortality was seen at parenteral dosages in excess of 6,000 mg/kg/day in all groups.
Symptoms: Common toxic signs in animals that died were a decrease in spontaneous activity, tonic and clonic convulsions, dyspnea, hypothermia, and cyanosis. Cefotaxime overdosage has occurred in patients. Most cases have shown no overt toxicity. The most frequent reactions were elevations of BUN and creatinine.
Treatment: Carefully observe patients who receive an acute overdosage and give supportive treatment.
