Cipol-N Overdosage

The oral LD₅₀ of cyclosporine is about 2.3, 1.5 or greater than 1 g/kg in mice, rats, and rabbits, respectively.
The IV LD₅₀ is 148, 104, or 46 mg/kg in mice, rats, and rabbits, respectively.
Symptom: Overdosage of cyclosporine is likely to produce symptoms that are mainly extensions of common adverse reactions. Transient hepatotoxicity and nephrotoxicity may occur but should resolve following elimination or discontinuance of the drug.
Treatment: In acute oral cyclosporine overdose, the stomach should be emptied by inducing emesis. Induction of emesis is probably useful up to 2 hours after ingestion. If the patient is comatose, having seizures, or lacks the gag reflex, gastric lavage may be performed if an endotracheal tube with cuff inflated is in place to prevent aspiration of gastric contents. Supportive and symptomatic treatment should be initiated. Hemodialysis and charcoal hemoperfusion reportedly are not useful for enhancing the elimination of cyclosporine following overdosage. When overdosage occurs in patients prescribed cyclosporine therapy, the drug may be withheld for a few days or alternate-day therapy may be initiated until the patient is stabilized.