Transplantation indications: Solid organ transplantation: Prevention of graft rejection following kidney, liver, heart, combined heart lung, lung or pancreas allogeneic transplantations. Treatment of transplant rejection in patients previously receiving other immunosuppressive agents.
Bone marrow transplantation: Prevention of graft rejection following bone marrow transplantation. Prevention or treatment of graft-versus-host disease (GVHD).
Non-transplantation indications: Endogenous uveitis: Treatment of active sight-threatening intermediate or posterior uveitis of non-infectious aetiology in patients where conventional therapy fails, or cause unacceptable side effects.
Treatment of Behçet uveitis with repeated inflammatory attacks involving the retina.
Nephrotic syndrome: Steroid-dependent and steroid-resistant nephrotic syndrome in adults and children, due to glomerular diseases such as minimal change nephropathy, focal and segmental glomerulosclerosis, or membranous glomerulonephritis. Cipol-N can be used to induce remissions and to maintain them. It can also be used to maintain steroid-induced remission, allowing withdrawal of steroids.
Rheumatoid arthritis: Treatment of severe, active rheumatoid arthritis.
Psoriasis: Treatment of severe psoriasis in patients in whom conventional therapy is ineffective or inappropriate.
Atopic dermatitis: Cipol-N is indicated in patients with severe atopic dermatitis when systemic therapy is required.