Brizagan

Brizagan

brimonidine

Manufacturer:

Rafarm S.A.

Distributor:

Zuellig Pharma

Marketer:

Mega Lifesciences
Concise Prescribing Info
Contents
Brimonidine tartrate
Indications/Uses
Reduction of elevated IOP in patients w/ open angle glaucoma or ocular HTN as monotherapy in patients in whom topical β-blocker therapy is contraindicated or as adjunctive therapy to other IOP lowering medications when target IOP is not achieved w/ single agent.
Dosage/Direction for Use
Adult including elderly 1 drop in affected eye(s) bid, approx 12 hr apart.
Contraindications
Hypersensitivity. Patients receiving MAOI therapy & on antidepressants affecting noradrenergic transmission eg, TCA & mianserin. Neonates & infants <2 yr.
Special Precautions
Discontinue treatment if allergic reactions are observed. Delayed ocular hypersensitivity reactions. Patients w/ severe or unstable & uncontrolled CV disease; depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans. Dry eye patients & in those where cornea may be compromised. Remove contact lenses prior to application & wait at least 15 min before reinsertion. Avoid contact w/ soft contact lenses. Monitor patients in case of prolonged use. May impair ability to drive or operate machinery. Hepatic or renal impairment. Pregnancy. Not to be used during lactation. Not recommended in childn <12 yr. Closely monitor childn ≥2 yr (especially 2-7 yr weighing ≤20 kg) due to high incidence & severity of somnolence. Adolescents 12-17 yr.
Adverse Reactions
Headache, drowsiness; ocular irritation (hyperaemia, burning & stinging, pruritus, foreign body sensation, conjunctival follicles), blurred vision, allergic blepharitis, blepharoconjunctivitis & conjunctivitis, ocular allergic reaction, & follicular conjunctivitis; oral dryness; fatigue. Dizziness, abnormal taste; local irritation (eyelid hyperaemia & oedema, blepharitis, conjunctival oedema & discharge, ocular pain & tearing), photophobia, corneal erosion & staining, ocular dryness, conjunctival blanching, abnormal vision, conjunctivitis; upper resp symptoms; GI symptoms; asthenia.
Drug Interactions
Possible additive or potentiating effect w/ CNS depressants eg, alcohol, barbiturates, opiates, sedatives, or anaesth. Concomitant use w/ medications affecting metabolism & uptake of circulating amines eg, chlorpromazine, methylphenidate, reserpine; antihypertensives &/or cardiac glycosides; adrenergic receptor agonists or antagonists eg, isoprenaline, prazosin.
MIMS Class
Antiglaucoma Preparations
ATC Classification
S01GA07 - brimonidine ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
S01EA05 - brimonidine ; Belongs to the class of sympathomimetics used in the treatment of glaucoma.
Presentation/Packing
Form
Brizagan eye drops 0.2% w/v
Packing/Price
10 mL x 1's
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