Brizagan Dosage/Direction for Use

Posology: Recommended dosage in adults (including the elderly): The recommended dose is one drop of Brizagan in the affected eye(s) twice daily, approximately 12 hours apart. No dosage adjustment is required for the use in elderly patients.
Use in renal and hepatic impairment: Brizagan has not been studied in patients with hepatic or renal impairment (see Precautions).
Paediatric population: No clinical studies have been performed in adolescents (12 to 17 years).
Brizagan is not recommended for use in children below 12 years and is contraindicated in neonates and infants (less than 2 years of age) (see Contraindications, Precautions and Overdosage). It is known that severe adverse reactions can occur in neonates. The safety and efficacy of Brizagan have not been established in children aged 2 to 12 years.
Method of administration: As with any eye drops, to reduce possible systemic absorption, it is recommended that the lachrymal sac be compressed at the medial canthus (punctal occlusion) for one minute. This should be performed immediately following the instillation of each drop. This may result in a decrease of systemic side effects and an increase in local activity. To avoid contamination of the eye or eye drops do not allow the dropper tip to come into contact with any surface.
If more than one topical ophthalmic drug is to be used, the different drugs should be instilled 5-15 minutes apart.