Acute & chronic treatment of the signs & symptoms of OA & RA. Ankylosing spondylitis. Acute gouty arthritis. Relief of chronic musculoskeletal pain including chronic low back pain; acute pain including dental surgery. Primary dysmenorrhea; moderate to severe post-op pain associated w/ abdominal gynecological surgery.
View Biocoxib overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Patients w/ moderate to severe heart failure (NYHA II-IV), renal impairment (CrCl <30 mL/min), ischemic heart disease, peripheral arterial disease or cerebrovascular disease, severe hepatic impairment (Child-Pugh score of ≥10); HTN whose BP is not controlled; active GI ulceration or bleeding, inflammatory bowel disease.
Risk of thrombotic events. Do not administer to patients whose BP is persistently >140/90 mmHg & inadequately controlled. Control BP prior to starting treatment & monitor for 2 wk regularly, thereafter. Avoid in patients w/ hepatic impairment; avoid in severe liver disease (Child-Pugh ≥10); active GI ulceration or bleeding; renal impairment. Monitor renal function. Avoid in patients w/ eGFR <30 mL/min/1.73 m2. Pregnancy & lactation.
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