BIOCOXIB (90 mg) contraindicated in: Patients with known hypersensitivity to any component of this product.
Patients with moderate to severe heart failure (NYHA II-IV).
Patients with renal impairment associated with a creatinine clearance < 30 ml/min.
Patients with ischemic heart disease, peripheral arterial disease or cerebrovascular disease.
Patients with severe hepatic impairment (Child-Pugh score of 10 or more).
Patients with hypertension whose blood pressure is not controlled.
Patients with active gastro-intestinal ulceration or bleeding.
Patients with inflammatory bowel disease.