IV Individualized dosage.
Control of bleeding episodes: Minor (early hemarthrosis, minor muscle/oral bleeds) 20-40 IU/dL infusion every 12-24 hr for at least 1 day, depending on the severity,
moderate (bleeding into muscles/oral cavity, mild head trauma) 30-60 IU/dL infusion every 12-24 hr for 3-4 days or until adequate local hemostasis is achieved,
major (GI, intracranial, intra-abdominal or intrathoracic bleeding, fractures) 60-100 IU/dL infusion every 8-24 hr until bleeding is resolved.
Routine & surgical prophylaxis: Minor surgery 30-60 IU/dL infusion every 12-24 hr for 3-4 days or until adequate local hemostasis is achieved,
tooth extraction Single infusion of 30-60 IU/dL plus oral antifibrinolytic therapy w/in 1 hr,
major surgery 60-100 IU/dL infusion every 8-24 hr until threat is resolved, or in the case of surgery, until adequate local hemostasis & wound healing are achieved.
Prophylaxis Childn <12 yr Recommended starting regimen: 25 ± 5 IU/kg every other day.
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