Obutin Mechanism of Action

Pharmacology: Obutin exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscles.
It exhibits no blocking effects at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects).
Obutin relaxes bladder smooth muscle in patients with conditions characterized by involuntary bladder contractions. Cystometric studies have demonstrated that Obutin increases bladder capacity, diminishes the frequency of uninhibited contractions of the detrusor muscle and delays the intial desire to void. It decreases urgency and the frequency of both incontinent episodes and voluntary urination.
Obutin was well tolerated in patients administered the drug in controlled studies of 30 days' duration and in uncontrolled studies in which some of the patients received Obutin for 2 years.