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Pharmacology: Pharmacodynamics: Ispaghula husk is capable of absorbing up to 40 times its own weight in water. Ispaghula husk consists 85% water-soluble fiber, it is partly fermentable and acts by hydration in the bowel. The pharmacological effects, gut motility and transit rate can be modified by the Ispaghula husk through mechanical stimulation of the gut wall depending on the increase in intestinal bulk by water and the decrease in viscosity of the luminal contents
Pharmacokinetics: Absorption: The material hydrates and swells to form a mucilage because it is only partially solubilised. Less than 10% of the mucilage gets hydrolysed in the stomach.
Progress of action: Ispaghula husk usually acts within 12 to 24 hours after single administration.
Elimination: Human intestinal flora in the large intestine degrades the polysaccharides.
