Mendicof

Dexchlorpheniramine maleate, dextromethorphan HBr, pseudoephedrine HCl.

Each 5ml contains Dexchlorpheniramine maleate 2 mg, dextromethorphan HBr 15 mg, pseudoephedrine HCl 30 mg.

For relief from such symptoms as nasal congestion, postnasal drip, sinusitis and rhinitis, and also relief of cough.

Adult & children above 12 yrs: 10 ml tds.
Children 6 to 12 years: 5 ml tds.
Administration: All doses to be taken after food.
Mendicof is not to be administered to patients below 2 years unless under medical advice and supervision.

This formula is contraindicated in patients exhibiting hypersensitivity to any of the components. Anti-histamines are contraindicated in patients receiving mono-amine oxidase inhibitors since these agents prolong and intensify the anti-cholinergic effects of anti-histamines. Anti-histamines should not be used to treat lower respiratory tract symptoms. It is contraindicated in patients with severe hypertension, severe coronary artery disease and in patients' receiving MAO inhibitor therapy due to potentiation of the pressor effects of phenylpropanolamine.
It is also contraindicated in asthmatic patients as it causes the release of histamine.

Sympathomimetics should be used with caution in patients with hypertension, hyperthyroidism, diabetes mellitus and cardiovascular disease. Anti-histamines should be used with caution in patients with narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy and bladder neck obstruction.
Anti-histamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers). Patients should be warned about engaging in activities requiring mental alertness such as driving a car or operating machinery.
Anti-histamines are more likely to cause dizziness, sedation and hypertension in elderly patients. Overdosage of sympathomimetics in this age group may cause hallucinations, convulsions, CNS depressions and death in elderly patients.
Monoamines oxidase inhibitors prolong and intensify the anti-cholinergic effects of anti-histamines and potentiate the pressors effects of sympathomimetics.
Sympathomimetics may reduce the anti-hypertensive effects of methyldopa, mecamylamine, reserpine and veratium alkaloids.
As in adults, the combination of an anti-histamine and sympathomimetic can elicit either mild stimulation or mild sedation in children. In the young child, mild stimulation is the response most frequently seen. In infants and children, overdosage of anti-histamines may cause hallucinations, convulsions or death.

General: Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of mouth, nose and throat.
Cardiovascular system: Hypotension, headache, palpitations, tachycardia, extrasystoles.
Nervous system: sedation, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesias, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, hysteria, neuritis, convulsions, CNS depression, hallucinations.
G.I. system: Epigastric distress, anorexia, nausea, vomiting, diarrhoea, constipation.
G.U. system: Urinary frequency, difficult urination, urinary retention.
Respiratory system: Thickening of bronchial secretions, tightness of chest, wheezing, nasal stuffiness.

Store at or below 25°C. Protect from light.

Cough & Cold Preparations

R05DA20 - combinations ; Belongs to the class of opium alkaloids and derivatives. Used as cough suppressant.

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