Mendicof Special Precautions

Sympathomimetics should be used with caution in patients with hypertension, hyperthyroidism, diabetes mellitus and cardiovascular disease. Anti-histamines should be used with caution in patients with narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy and bladder neck obstruction.
Anti-histamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers). Patients should be warned about engaging in activities requiring mental alertness such as driving a car or operating machinery.
Anti-histamines are more likely to cause dizziness, sedation and hypertension in elderly patients. Overdosage of sympathomimetics in this age group may cause hallucinations, convulsions, CNS depressions and death in elderly patients.
Monoamines oxidase inhibitors prolong and intensify the anti-cholinergic effects of anti-histamines and potentiate the pressors effects of sympathomimetics.
Sympathomimetics may reduce the anti-hypertensive effects of methyldopa, mecamylamine, reserpine and veratium alkaloids.
As in adults, the combination of an anti-histamine and sympathomimetic can elicit either mild stimulation or mild sedation in children. In the young child, mild stimulation is the response most frequently seen. In infants and children, overdosage of anti-histamines may cause hallucinations, convulsions or death.